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目的:探讨臭氧联合玻璃酸钠关节腔注射治疗膝骨性关节炎的临床疗效及对患者炎症因子和血液流变学指标的影响。方法:选取2016年10月至2019年2月于本院接受治疗的膝骨性关节炎患者146例，按随机数字表法分为观察组和对照组，每组73例。观察组采用臭氧联合玻璃酸钠关节腔内注射，对照组常规服用盐酸氨基葡萄糖片，同时关节腔内注射玻璃酸钠，两组患者均每周治疗1次，连续5周为1个疗程。分析两组患者的一般资料，比较两组患者的疗效，治疗前后VAS评分和美国纽约特种外科医院膝关节功能评分(HSS)、炎症因子水平以及血液流变学指标变化。结果:治疗前，两组患者VAS评分和HSS评分的差异均无统计学意义(n P>0.05)；治疗后，两组患者VAS评分和HSS评分分别显著降低和升高(n P0.05). After treatment, VAS score and HSS score in the two groups were significantly decreased and increased respectively (n P<0.05). Compared with the control group, VAS score was significantly decreased and HSS score was significantly increased in the observation group after treatment (n P<0.05). The total effective rate in the observation group was higher than that in the control group, and the difference between the two groups was statistically significant (n P0.05). After treatment, the above indexs in the observation group were significantly lower than those in the control group (n P<0.05). After treatment, the levels of inflammatory cytokines in the articular fluid of the two groups were lower than before (n P0.05), and the two groups were significantly improved after treatment, and the degree of improvement in the observation group was significantly better than that in the control group (n P<0.05).n Conclusions:Ozone combined with sodium hyaluronate intra-articular injection is more effective in the treatment of knee osteoarthritis, which can effectively reduce the level of inflammatory factors and inflammatory response, improve hemorheology, and then reduce the pain of patients, improve the knee joint function.