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目的分析丘脑及基底节区生殖细胞瘤的临床、影像学特点,诊断性放疗及小剂量局部放疗加静脉化疗的治疗效果。方法回顾性分析了28例局限于丘脑及基底节区经诊断性放疗证实的生殖细胞瘤的临床特点和疗效。患者肿瘤局部照射剂量为35-40Gy/3-4周。放疗后1个月行 VMPP化疗两疗程,每间隔6个月复查MRI,随访时间1-3．5年。结果所有病例均无瘤生存,无复发,未见放射性损伤。但患者肿瘤对侧的肢体运动障碍无明显改善。结论丘脑及基底节区生殖细胞瘤有独特的影像学特点,通过诊断性放疗可以进一步确诊。
Objective To analyze the clinical and imaging characteristics of thalamic and basal ganglia germ cell tumors, diagnostic radiotherapy and low-dose local radiotherapy plus intravenous chemotherapy. Methods The clinical features and therapeutic effects of 28 germ cell tumors confirmed by diagnostic radiotherapy in the thalamus and basal ganglia were retrospectively analyzed. Patient tumor local exposure dose of 35-40Gy / 3-4 weeks. One month after radiotherapy VMPP chemotherapy two courses, every 6 months review MRI, follow-up time of 1-3.5 years. Results All cases were tumor-free, no recurrence and no radioactive injury. However, patients with contralateral limb movement disorders did not improve significantly. Conclusion The thalamus and basal ganglia germ cell tumor have unique imaging features, which can be further confirmed by diagnostic radiotherapy.