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爆式集落刺激活性(Burst-Promoting Activity,BPA)系指一组具有造血调控作用的物质的活性。对于体外培养的早期红系造血祖细胞(BFU-E),BPA具有维持其生存、促进其增殖、分化的作用。自从Dukes和Nissen分别自再生障碍性贫血(再障)病人尿液及血清中发现较正常人为高的BPA以来,国外一些学者对BPA与再障的关系做了许多工作。下面仅就此作一文献复习。一、BPA的来源、生物学作用及其理化特性人及小鼠红系造血祖细胞是一个异质性的群体。在进行体外半固体培养时,可以产生3种不同的集落形式:早期BFU-E、晚期BFU-E及CFU-E。这3种集落分别起源于3种分
Burst-Promoting Activity (BPA) refers to the activity of a group of substances that have a role in hematopoietic regulation. For the early erythroid hematopoietic progenitor cells (BFU-E) cultured in vitro, BPA can maintain its survival and promote its proliferation and differentiation. Since Dukes and Nissen found higher levels of BPA in the urine and serum of patients with aplastic anemia (aplastic anemia) than normal controls respectively, some foreign scholars have done a lot of work on the relationship between BPA and aplastic anemia. Here is a review of the literature. First, the source of BPA, biological effects and physical and chemical properties of human and mouse erythroid hematopoietic progenitor cells is a heterogeneous group. In vitro semi-solid culture, can produce three different colony forms: early BFU-E, advanced BFU-E and CFU-E. These three kinds of colonies originated in three kinds of points respectively