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早在40年代初,Freedburg即发现胃切除标本的粘膜上存在螺旋状细菌,由于当时沾膜活体组织取材困难而未能被他人证实。1975年Steer提出80％胃溃疡患者在粘膜上皮表面存在革兰氏阴性细菌,当时又误认为是内镜污染所致,故再次未能引起重视。1983年Warren和Marshall报告在135份周活检标本的上皮细胞表面检出弯曲形或S形细菌,并成功地予以分离、培养。随后,很多报告均证实胃炎和消化性溃疡病
As early as the early 1940s, Freedburg found that there was helical bacteria in the mucosa of gastrectomy specimens, which could not be confirmed by others because of the difficulties in obtaining the living tissues of the mucosa. Steer in 1975, 80% of gastric ulcer patients in the presence of gram-negative bacteria on the surface of the mucosal epithelium, was mistaken for endoscopic contamination, it again failed to pay attention. In 1983, Warren and Marshall reported the detection of curved or S-shaped bacteria on the surface of epithelial cells of 135 biopsies and successfully isolated and cultured them. Subsequently, many reports confirm gastritis and peptic ulcer disease