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近年证实动脉粥样硬化病灶中泡沫细胞来源于单核巨噬细胞，已发现糖尿病患者糖基化低密度脂蛋白（ＬＤＬ）水平增高，代谢异常。本文以放射受体分析法比较１２例糖尿病患者及１２例年龄。性别配对的健康人血ＬＤＬ在人外周血巨噬细胞中的代谢，发现糖尿病患者ＬＤＬ的摄入和降解明显高于对照组，与其孵育过的巨噬细胞内胆固醇明显增高。提示糖尿病患者ＬＤＬ与巨噬细胞相互作用易形成泡沫细胞，高血糖引起的ＬＤＬ糖基化及其代谢异常可能是糖尿病人易患动脉粥样硬化的重要机制之一。
In recent years confirmed that atherosclerotic lesions in foam cells derived from mononuclear macrophages, diabetes has been found in patients with elevated levels of glycosylated low density lipoprotein (LDL), metabolic abnormalities. In this paper, 12 cases of diabetes mellitus and 12 cases of age were compared by radioimmunoassay. Gender-matched healthy human blood LDL metabolism in human peripheral blood macrophages found that LDL intake and degradation in diabetic patients was significantly higher than that in the control group, and macrophages incubated with it significantly increased cholesterol. It is suggested that the interaction between LDL and macrophages in diabetic patients tends to form foam cells. The hyperglycemia-induced LDL glycosylation and its metabolic abnormalities may be one of the important mechanisms of diabetic susceptibility to atherosclerosis.