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尽管新的抗生素和其他辅助治疗手段已广泛应用,但由革兰氏阴性菌感染引起的死亡率并未降低,发病率仍在上升,其中大肠杆菌占30%～45%。已知大肠杆菌毒性因子包括纤毛粘附素P和S、非纤毛粘附素AFA以及a-溶血素等,但它们在大肠杆菌菌血症病原学中的作用仍不清楚。作者在美国两所医院167名菌血症患者的173例血样中分离到174株大肠杆菌,对其中170株来源于不同原发部位的大肠杆菌进行基因型和表型分析,检测了编码毒性因子的相关操纵子在这些菌株中的分布,同时
Despite the widespread use of new antibiotics and other adjuvant therapies, mortality caused by Gram-negative infections has not decreased and morbidity has risen, with E. coli accounting for 30% to 45%. E. coli virulence factors are known to include ciliated adhesins P and S, non-ciliated adhesin AFA and a-hemolysin, etc., but their role in the etiology of E. coli etiology remains unclear. The authors isolated 174 Escherichia coli strains from 173 blood samples from 167 patients with bacteremia in two hospitals in the United States. Genotype and phenotype analysis was performed on 170 Escherichia coli strains of different origin, The distribution of the relevant operons in these strains, at the same time