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作者报导两例再生障碍性贫血患者长期给予促蛋白合成激素疗法(AST)后发生肝细胞癌。例1,男性,29岁,再生障碍性贫血史15年。1972年起给予AST,血象并未改善。1982年血红蛋白值(Hb)和血小板数(BPC)开始下降,需频繁输血。1983年经4疗程冲击量甲基强的松龙和1疗程抗淋巴细胞球蛋白治疗,仍未改善。1985年5月发热,肝功能异常。腹部CT扫描和超声检查示肝左叶有一直径
The authors report that two patients with aplastic anemia developed hepatocellular carcinoma after long-term administration of anabolic hormone therapy (AST). Example 1, male, 29 years old, history of aplastic anemia 15 years. AST given since 1972, blood did not improve. 1982 hemoglobin value (Hb) and platelet count (BPC) began to decline, requiring frequent transfusions. In 1983 after 4 courses of treatment of methylprednisolone and 1 course of anti-lymphocyte globulin treatment, still no improvement. May 1985 fever, abnormal liver function. Abdominal CT scans and ultrasonography showed a diameter of the left hepatic lobe