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目的 :探讨NSE、MBP与HIE脑损伤程度的关系。方法 :用双抗体夹心酶联免疫法测脑脊液中NSE、MBP。结果 :(1)临床分度各组NSE的含量与脑损伤程度一致。 (2 )临床分度各组MBP的含量仅于重度组显著升高。 (3)临床轻、重度患儿CT分度与临床基本一致 ,而临床中度的患儿CT分度与临床分度并不完全一致。 (4)CT分度各组脑脊液中NSE、MBP含量均无差异。结论 :脑脊液中NSE可作为早期判断HIE脑损伤程度的生化指标。MBP增高说明脑损伤严重。生后一周后作头颅CT检查不能准确反映脑损伤程度。
Objective: To investigate the relationship between NSE, MBP and brain injury in HIE. Methods: NSE and MBP in cerebrospinal fluid were detected by double antibody sandwich enzyme-linked immunosorbent assay. Results: (1) The clinical index of NSE in each group was consistent with the degree of brain injury. (2) Clinical index The content of MBP in each group only increased significantly in severe group. (3) Clinical classification of patients with mild and severe CT is basically consistent with the clinical, and clinical degree of clinical CT in patients with sub-indexing and clinical sub-degree is not entirely consistent. (4) There was no difference in the contents of NSE and MBP in cerebrospinal fluid between CT groups. Conclusion: NSE in cerebrospinal fluid can be used as a biochemical indicator of early brain injury in HIE. MBP increased brain damage is serious. A week after birth for head CT examination can not accurately reflect the degree of brain damage.