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Objective: To examine whether the birth weight (BW) and the risks of being preterm, low birth weight (LBW), and small for gestational age (SGA) of children with cystic fibrosis (CF) are different from nonaffected children. Study design: Retrospective cohort study. We examined all the children with CF born in Tuscany, Italy, from 1991 to 2002 (n = 70) comparing them to the entire population of non-CF-affected children born in the same period (n = 290,059). Results: The mean BW of newborns with CF was 2462 g lower than the mean BW of the non-CF neonatal population (P = .0003). Children with CF had a higher risk of being born preterm (RR 2.62, P = .001), LBW(RR 2.66, P = .0009), and SGA (RR 1.74, P = .04) than the non-CF-affected children. The mean BW of term newborns with CF was 2057 g lower than that of term non-CF-affected babies (P = .0002). Conclusions: Our data show an association between CF and reduced BW and show a greater risk of being preterm for babies with CF.
Objective: To examine whether the birth weight (BW) and the risks of being preterm, low birth weight (LBW), and small for gestational age (SGA) of children with cystic fibrosis (CF) are different from nonaffected children. Study design: We examined all the children with CF born in Tuscany, Italy, from 1991 to 2002 (n = 70) comparing them to the entire population of non-CF-affected children born in the same period (n = 290,059). Children with CF had a higher risk of being born preterm (RR 2.62, P = .001 ), LBW (RR 2.66, P = .0009), and SGA (RR 1.74, P = .04) than the non-CF-affected children. The mean BW of term newborns with CF was 2057 g lower than that of term non -CF-affected babies (P = .0002). Conclusions: Our data show an association between CF and reduced BW and show a greater risk of being preterm for babies with CF.