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疾病相似性研究对于复杂疾病发病机制的理解、诊断、预测和药物研发具有重要意义.最近,研究人员通过集成多种疾病术语库,构建了描述疾病关系的疾病本体(disease ontology,DO),这为从DO角度研究疾病相似性打下了基础.本文综述了基于DO及其注释信息的疾病相似性计算方法,探讨了疾病相似性计算存在的问题和挑战,为疾病相似性进一步的研究提供有益参考.
The study of disease similarity is of great importance for the understanding, diagnosis, prediction and drug discovery of the pathogenesis of complex diseases.Recently, the researchers constructed a disease ontology (DO) that describes the relationship between diseases through the integration of a variety of disease terminology databases Which paves the way for the study of disease similarity from DO perspective.This paper summarizes the method of disease similarity calculation based on DO and its annotation information and discusses the problems and challenges in the calculation of disease similarity so as to provide useful reference for the further study of disease similarity .