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目的观察不同剂量米非司酮配伍米索前列醇用于妊娠10～14周流产的疗效。方法选择妊娠10～14周自愿接受药物流产的健康孕妇100例,分为观察组和对照组,每组各50例。两组妇女均应用米非司酮配伍米索前列醇流产,观察组米非司酮的总剂量为300mg,对照组米非司酮的总剂量为150mg,给药时间、方法及其他处理措施均相同。观察流产的完全性,阴道出血量及不良反应。结果流产有效率观察组高于对照组(P<0.05),阴道出血量观察组少于对照组(P<0.05),但不良反应两组差异无统计学意义(P>0.05)。结论大剂量米非司酮配伍米索前列醇终止10～14周妊娠流产成功率高,不良反应小,是一种方便、有效、较为安全的药物流产方法。
Objective To observe the effect of different doses of mifepristone and misoprostol for miscarriage in 10-14 weeks gestation. Methods 100 healthy pregnant women who volunteered medical abortion from 10 to 14 weeks of pregnancy were selected and divided into observation group and control group with 50 cases in each group. Both groups of women were treated with mifepristone combined with misoprostol abortion, the total dose of mifepristone observation group 300mg, the total dose of mifepristone 150mg, administration time, methods and other treatment measures the same. To observe the complete abortion, vaginal bleeding and adverse reactions. Results The effective rate of abortion in observation group was higher than that in control group (P <0.05). The vaginal bleeding volume in observation group was less than that in control group (P <0.05). However, there was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion High-dose mifepristone combined with misoprostol has a high success rate of abortion in 10-14 weeks of gestation and low adverse reactions, which is a convenient, effective and safe method of medical abortion.