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1961年Myrrik等首先通过灌洗正常兔肺取得高纯度肺泡巨噬细胞,后Finley等(1967)从正常人和阻塞性肺脏疾病患者的支气管肺泡灌洗液中收集到人肺泡巨噬细胞(PAM)。近年来,由于广泛应用纤维支气管镜,使在不同肺脏疾病患者中常规收集PAM成为可能,为研究PAM在肺脏生理、病理生理中的地位提供了重要方法和条件。PAM指肺组织局部的、具有某种独特功能的单核吞噬细胞,它不仅具有吞噬、杀灭病原微生物的能力,同时也能吞噬衰老的Ⅰ型、Ⅱ型肺泡上皮细胞、红细胞、甚至
In 1961, Myrrik et al first obtained high-purity alveolar macrophages by lavage of normal rabbit lungs. Finley et al. (1967) collected human alveolar macrophages (PAMs) from bronchoalveolar lavage fluid from normal and obstructive pulmonary disease patients (PAM ). In recent years, due to the extensive use of fiberoptic bronchoscopy, the routine collection of PAM in patients with different lung diseases is possible, which provides important methods and conditions for studying the status of PAM in lung physiology and pathophysiology. PAM refers to the local lung tissue, with some unique features of mononuclear phagocytes, it not only has phagocytosis, the ability to kill pathogenic microorganisms, but also phagocytosis of aging type I and type II alveolar epithelial cells, red blood cells, and even