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目的 找到合适途径来制备所设计的CPP32抑制剂。方法 Ugi四组分缩合反应用于合成拟肽类CPP32抑制剂。结果 合成了关键异腈组分 (天冬氨酸衍生异腈 3)和CPP32抑制剂模板分子 4。结论 以基于天冬氨酸衍生异腈 3的Ugi四组分缩合反应 ,合成了CPP32抑制剂 4。此新建的方法可用于构建CPP32拟肽类抑制剂化学库。
Objective To find a suitable route to prepare the designed CPP32 inhibitor. Methods Ugi four-component condensation reaction was used to synthesize the peptidomimetic CPP32 inhibitor. Results The key isonitrile component (aspartate derived isonitrile 3) and CPP32 inhibitor template molecule 4 were synthesized. Conclusion CPP32 inhibitor 4 was synthesized based on the Ugi four - component condensation reaction of aspartic acid - derived isonitrile 3. This new method can be used to construct the CPP32 peptidomimetic inhibitor chemical library.