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无论在发达国家或发展中国家,轮状病毒(RV)都是引起儿童严重急性腹泻的重要病因.RV在儿童腹泻死亡中的比例尚未确定,但估计每年RV相关腹泻死亡人数为50万.这个数字仅代表急性腹泻的死亡数.此外,还有因腹泻营养不良复征而死亡者,RV感染可能在其中起一定作用.鉴于这种情况,发展中国家对RV疫苗的需要是毋庸置疑的.在发达国家中,RV在儿童期急性腹泻病因中的比例较大,为50～60%,这是由于目前在西欧和美国细菌性肠道病原体数目较少的缘故.芬兰的资料表明,50年代到70年代,儿童急性腹泻的流行病学模式已发生了根本改变,流行高峰从夏季转移到了冬季.6月
Rotavirus (RV) is a major cause of severe acute diarrhea in children, both in developed and developing countries.The proportion of RV in children with childhood diarrhea has not yet been determined, but the estimated annual number of RV-related diarrhea deaths is 500 000. This The numbers represent only the number of deaths from acute diarrhea and, in addition, those who died of a diarrheal malnutrition syndrome may have a role to play in RV infection. Given this situation, the need for RV vaccines in developing countries is beyond doubt. In developed countries, the proportion of RV in the etiology of childhood acute diarrhea is large at 50-60%, due to the small number of bacterial enteric pathogens in Western Europe and the United States at present.Finland data indicate that in the 1950s By the 1970s, the epidemiological pattern of acute diarrhea in children had changed fundamentally, with the peak of the epidemic shifting from summer to winter.