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神经细胞培养的第3天或第5天给人参皂甙(87μg/ml)可使培养第10天的神经细胞的胆碱酯酶活性显著增强和高峰提前;但培养到第14天时,培养第3天给人参皂甙比培养第5天给人参皂甙的神经细胞胆碱酯酶活性强约2.5倍.培养第3天给人参皂甙比培养第5天给人参皂甙对神经细胞胆碱酯酶活性的增强作用更好.细胞分裂抑制剂氨甲基喋呤能显著地减弱培养神经细胞胆碱酯酶活性,而人参皂甙能减轻氨甲基喋呤对培养神经细胞胆碱酯酶活性的减弱.初步认为,人参皂甙促进培养神经细胞胆碱酯酶活性的增强是因为它促进了神经细胞的分化成熟、分裂增殖和存活.
Ginsenoside (87 μg / ml) on day 3 or 5 of nerve cell culture significantly increased the cholinesterase activity of nerve cells on the 10th day of culture, and peaked earlier; however, on the 14th day of culturing, cells in culture 3 Day give ginsenoside more than 2.5 times of cholinesterase activity of ginsenoside-derived nerve cells on the fifth day of culture.Ginsenoside on day 3 of culture gave ginsenoside more activity on cholinesterase of nerve cell than day 5 of culture The effect is better.The cell division inhibitor aminomethyl-epinephrine can significantly reduce the activity of nerve cell choline esterase, while ginsenosides can reduce the aminomethyl-methotrexate on cultured nerve cell cholinesterase activity was reduced , Ginsenosides promote nerve cell cholinesterase activity increased because it promotes neural cell differentiation and maturation, division and proliferation and survival.