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目的研究高渗盐水(HS)对心搏骤停复苏后组织的保护作用探讨心肺脑复苏治疗的有效方法。方法家兔窒息导致心搏骤停模型复制成功后6 min开始复苏,两组于复苏即刻分别静脉注射生理盐水、7.5%高渗盐水(HS)比较两组家兔复苏前及复苏后各时间点心输出量、中心静脉压、肺毛细血管楔压、动脉血肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的浓度。结果两组家兔复苏前心输出量、中心静脉压、肺毛细血管楔压、TNF-α、IL-6的浓度差异无统计学意义(P>0.05),而复苏后各时间点心输出量、中心静脉压值HS组均高于对照组(P<0.05);高渗盐组较对照组能显著减轻组织炎性反应,两组TNF-α、IL-6的浓度差异有统计学意义。结论静脉注射7.5%HS能量加家兔心搏骤停复苏后的有效循环血量,改善全身重要脏器的灌注,减轻组织炎性反应,减少再灌注损伤。
Objective To study the protective effect of hypertonic saline (HS) on the tissue after cardioversion and resuscitation and to explore the effective method of cardiopulmonary and cerebral resuscitation. Methods Rabbits asphyxiated cardiac arrest model 6 minutes after successful replication began to recover, the two groups immediately after resuscitation, respectively, intravenous injection of saline, 7.5% hypertonic saline (HS) compared two groups of rabbits before and after resuscitation Output, central venous pressure, pulmonary capillary wedge pressure, arterial blood tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) concentrations. Results There was no significant difference in cardiac output, central venous pressure, pulmonary capillary wedge pressure, TNF-α and IL-6 concentrations before and after resuscitation in rabbits in both groups (P> 0.05) The central venous pressure value in HS group was higher than that in control group (P <0.05). Compared with control group, hypertonic saline group could significantly reduce the tissue inflammatory response, and the difference of TNF-α and IL-6 in two groups was statistically significant. Conclusion Intravenous injection of 7.5% HS plus effective circulating blood volume after cardioversion in rabbits ameliorates the perfusion of vital organs of the whole body, relieves the tissue inflammatory reaction and reduces the reperfusion injury.