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目的:探讨慢性乙型肝炎合并代谢综合征患者高危因素及其对慢性乙型肝炎病情的影响。方法:采用多阶段抽样的方法,选取我院2012年12月至2015年3月住院的慢性乙型肝炎患者200例,根据患者是否合并代谢综合征,分为两组:A组合并代谢综合征(44例),B组无代谢综合征(156例),比较两组的糖尿病和高血压家族史、膳食结构和生活方式、乙肝病毒感染史、乙型肝炎病程、肝功能、病毒载量等。结果:两组患者在糖尿病和高血压家族史、膳食结构和生活方式、乙型肝炎病程方面相比有显著差异(P<0.05),两组在乙肝病毒感染史、病毒载量等均无显著差异(P>0.05),提示糖尿病和高血压家族史、膳食结构和生活方式与慢性乙型肝炎合并代谢综合征发病有相关性。同时合并代谢综合征影响慢性乙型肝炎的病程。结论:慢性病毒性肝炎患者存在多种危险因素导致代谢综合征发生,应加强对相关危险因素的干预,预防肝病患者代谢综合征的发生,改善慢性乙型肝炎的进展。
Objective: To investigate the risk factors of patients with chronic hepatitis B complicated with metabolic syndrome and their effects on the severity of chronic hepatitis B. Methods: A multi-stage sampling method was used to select 200 patients with chronic hepatitis B who were hospitalized from December 2012 to March 2015 in our hospital. Patients were divided into two groups according to whether the patients had metabolic syndrome or not: group A with metabolic syndrome (44 cases) and no metabolic syndrome (156 cases) in group B. The family history of diabetes and hypertension, dietary structure and lifestyle, history of hepatitis B virus infection, duration of hepatitis B, liver function, viral load, etc. were compared between the two groups . Results: There was a significant difference between the two groups in the family history of diabetes and hypertension, dietary structure, lifestyle and duration of hepatitis B (P <0.05). There was no significant difference in the history of hepatitis B virus infection and viral load between the two groups (P> 0.05), suggesting that the family history of diabetes mellitus and hypertension, dietary structure and lifestyle were associated with the incidence of chronic hepatitis B with metabolic syndrome. Metabolic syndrome at the same time affect the course of chronic hepatitis B. Conclusion: There are many risk factors in patients with chronic viral hepatitis leading to metabolic syndrome. Intervention should be strengthened to prevent metabolic syndrome and improve the progress of chronic hepatitis B.