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目的探讨中晚期肝癌(HCC)患者接受抗甲胎蛋白抗体介导的双弹头导向药物治疗对细胞免疫功能的影响。方法采用碱性磷酸酶 -抗碱性磷酸酶法和51Cr释放试验 ,分别测定了HCC患者T细胞亚群数和NK细胞的活性。结果导向组患者用导向药物治疗后 ,其NK细胞和CD3 +T细胞、CD4 +T细胞数 ,CD4 +/CD8 +T细胞比值均无显著降低 ,CD8 +T细胞数无明显升高(P均>0.05) ;而化疗组患者做化疗后 ,其NK细胞的活性和CD3+ T细胞、CD4 +T细胞数 ,以及CD4 +/CD8 +T细胞的比值均显著降低 ,CD8+ T细胞数显著升高(P均<0.05)。结论该双弹头导向药物对HCC患者的细胞免疫功能无影响 ,而化疗患者的细胞免疫功能则明显下降。
Objective To investigate the effect of anti-alpha fetoprotein antibody-mediated dual warhead-directed drug therapy on cellular immune function in patients with advanced hepatocellular carcinoma (HCC). Methods Alkaline phosphatase - alkaline phosphatase and 51Cr release assay were used to determine the T cell subsets and NK cell activity in patients with HCC. Results In the guide-oriented group, the ratio of NK cells, CD3 + T cells, CD4 + T cells and CD4 + / CD8 + T cells was not significantly decreased and the number of CD8 + T cells was not significantly increased (P > 0.05). After chemotherapy, the NK cell activity and the ratio of CD3 + T cells, CD4 + T cells and CD4 + / CD8 + T cells in chemotherapy group were significantly decreased, and the number of CD8 + T cells was significantly increased P <0.05). Conclusion The dual warhead-directed drug has no effect on cellular immune function in patients with HCC, while the cellular immune function of chemotherapy patients decreased significantly.