Mouse models of colorectal cancer

• 作 者: H.Phillip Koeffler
• 机 构: Department of Medicine, Cedars-Sinai Medical Center,National Cancer Institute and Cancer Institute o
• 出 处: 癌症
• 发表日期: 2011年07期
• 关键词: colorectal colon chemically engineered HNPCC adenomatous metastasis intestine po

Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer.

Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer.