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目的:观察健脾和胃方联合多潘立酮片治疗功能性消化不良(FD)的临床疗效。方法:将100例脾胃虚弱型FD患者随机分为2组,每组50例。对照组口服多潘立酮片,治疗组以健脾和胃方联合多潘立酮片治疗。2组均以4周为1疗程。1疗程结束后,比较2组的临床疗效、治疗前后临床症状积分的变化与治疗结束3月后FD的复发率。结果:治疗后,总有效率治疗组为92.00%,对照组为74.00%,2组比较,差异有统计学意义(P<0.05)。2组腹胀、恶心呕吐、嗳气、反酸、上腹痛积分均较治疗前下降(P<0.05);治疗组食欲减退、倦怠乏力积分均较治疗前下降(P<0.05),而对照组此2项症状积分与治疗前比较无统计学差异(P>0.05)。治疗组恶心呕吐、食欲减退、倦怠乏力、上腹痛积分均低于对照组(P<0.05)。治疗组复发率为23.68%,对照组复发率为65.85%,2组比较,差异有统计学意义(P<0.05)。结论:健脾和胃方联合多潘立酮片治疗脾胃虚弱型FD临床疗效显著,可明显改善患者的临床症状,降低复发率。
Objective: To observe the clinical effects of Jianpi and Weifang combined with domperidone tablets in the treatment of functional dyspepsia (FD). Methods: 100 cases of spleen and stomach weak FD were randomly divided into two groups, 50 cases in each group. The control group oral domperidone tablets, the treatment group with spleen and stomach combined with domperidone tablets treatment. 2 groups were 4 weeks for a course of treatment. 1 after the end of treatment, the clinical efficacy of two groups were compared, before and after treatment, clinical symptom score changes and treatment of FD recurrence after 3 months. Results: After treatment, the total effective rate was 92.00% in the treatment group and 74.00% in the control group. There was significant difference between the two groups (P <0.05). The scores of abdominal distension, nausea and vomiting, belching, acid reflux and upper abdominal pain in 2 groups were significantly lower than those before treatment (P <0.05). The scores of appetite and fatigue in treatment group were lower than those before treatment (P <0.05) There was no significant difference between the symptom scores and before treatment (P> 0.05). Nausea and vomiting in the treatment group, loss of appetite, fatigue, upper abdominal pain points were lower than the control group (P <0.05). The recurrence rate was 23.68% in the treatment group and 65.85% in the control group. There was significant difference between the two groups (P <0.05). Conclusion: Jianpi and Weifang combined with domperidone tablets in treating spleen and weakness FD have obvious curative effect, which can obviously improve the clinical symptoms and reduce the recurrence rate.