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目的:研究金刚藤分散片(JDT)的抗炎镇痛作用。方法:采用小鼠耳廓肿胀模型、大鼠足跖肿胀模型和大鼠棉球肉芽肿模型来进行JDT的抗炎作用研究;采用小鼠扭体反应实验来进行JDT的镇痛作用研究;同时与阳性对照药金刚藤胶囊(JC)进行比较。结果:JDT对二甲苯所致小鼠耳廓肿胀、蛋清所致大鼠足跖肿胀、大鼠棉球所致肉芽肿、醋酸所致小鼠扭体反应均有显著抑制作用,其效果均优于阳性对照药JC(P<0.05)。结论:JDT具有良好的抗炎镇痛作用。
Objective: To study the anti-inflammatory and analgesic effects of Jingangteng Dispersible Tablets (JDT). METHODS: The mouse ear swelling model, rat paw edema model and rat granuloma model were used to study the anti-inflammatory effect of JDT. The mouse writhing response experiment was used to study the analgesic effect of JDT. Compare with the positive control drug Jingangteng Capsules (JC). RESULTS: JDT significantly inhibited mouse ear swelling caused by xylene, swelling of rat paws caused by egg white, granuloma caused by rat cotton balls, and writhing response induced by acetic acid in mice. The results were all excellent. Positive control drug JC (P <0.05). Conclusion: JDT has good anti-inflammatory and analgesic effects.