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AIM:To investigate the serum erythropoietin (Epo) levelsin patients with chronic liver diseases and to compare tosubjects with iron-deficiency anaemia and healthy controls.METHODS:We examined 31 anaemic (ALC) and 22 non-anaemic (NALC) cirrhotic patients,21 non-anaemic subjectswith chronic active hepatitis (CAH),24 patients with iron-deficiency anaemia (ID) and 15 healthy controls.CirculatingEpo levels (ELISA;R&D Systems,Europe Ltd,Abingdon,UK) and haemoglobin (Hb) concentration were determinedin all subjects.RESULTS:Mean±SD of Epo values was 26.9±10.8 mU/mLin ALC patients,12.5±8.0 mU/mL in NALC subjects,11.6±6.3 mU/mL in CAH patients,56.4±12.7 mU/mL in thecases of ID and 9.3±2.6 mU/mL in controls.No significantdifference (P>0.05) was found in Epo levels betweencontrols,CAH and NALC patients.ALC individuals had higherEpo levels (P<0.01) than these groups whereas ID subjectshad even higher levels (P<0.001) than patients sufferingfrom ALC.CONCLUSION:Increased Epo values in cirrhotics,are onlydetectable when haemoglobin was lesser than 12 g/dL.Nevertheless,this rise in value is lower than that observedin anaemic patients with iron-deficiency and appears bluntedand inadequate in comparison to the degree of anaemia.
AIM: To investigate the serum erythropoietin (Epo) levels in patients with chronic liver diseases and to compare tosubjects with iron-deficiency anaemia and healthy controls. METHODS: We examined 31 anaemic (ALC) and 22 non-anaemic (NALC) cirrhotic patients, 21 non-anaemic subjects with chronic active hepatitis (CAH), 24 patients with iron-deficiency anaemia (ID) and 15 healthy controls. CirculatingEpo levels (ELISA; R & D Systems, Europe Ltd, Abingdon, UK) and hemoglobin (Hb) Subjects.RESULTS: Mean ± SD of Epo values was 26.9 ± 10.8 mU / mL in ALC patients, 12.5 ± 8.0 mU / mL in NALC subjects, 11.6 ± 6.3 mU / mL in CAH patients, 56.4 ± 12.7 mU / mL in thecases of ID and 9.3 ± 2.6 mU / mL in controls. Significant differences (P> 0.05) were found in Epo levels between controls, CAH and NALC patients. ALC individuals had higher Epo levels (P <0.01) than these groups yet ID subjectshad even higher levels <0.001) than patients sufferingfrom ALC.CONCLUSION: Increased Epo values in cirrhotic s, are onlydetectable when haemoglobin was lesser than 12 g / dL.Nevertheless, this rise in value is lower than that observed in anaemic patients with iron-deficiency and appears bluntedand inadequate in comparison to the degree of anaemia.