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目的评价联用鼻渊舒口服液和盐酸氨溴索治疗慢性鼻窦炎的疗效及安全性。方法219例慢性鼻窦炎受试病例,随机分为甲、乙、丙三组。甲组联合应用鼻渊舒口服液和盐酸氨溴索,乙组单独服用鼻渊舒口服液,丙组单独服用盐酸氨溴索,均连续服用21天。分别对治疗前后的症状和体征进行记分量化评估,考核其疗效和安全性。结果甲组显效率明显高于乙组和丙组,P均<0.05。主要不良反应表现为胃胀、反酸、恶心,甲组出现8例(8/70,11.43%),乙组出现6例(6/66,9.09%),丙组出现7例(7/65,10.77%)。结论对Ⅰ型慢性鼻窦炎患者可首选鼻渊舒口服液联用盐酸氨溴索进行治疗,其疗效优于单用其中任一种药物,而且药物的安全性也好。
Objective To evaluate the efficacy and safety of nasosinusitis oral solution and ambroxol hydrochloride in the treatment of chronic sinusitis. Methods 219 cases of chronic sinusitis were randomly divided into three groups: A, B and C. Group A combination of nasal fluid and ambroxol hydrochloride ambroxol, B group taking nasal fluid alone oral solution, C alone taking ambroxol hydrochloride, were taken continuously for 21 days. Respectively before and after treatment of symptoms and signs scoring quantitative assessment of its efficacy and safety. Results The effective rate of group A was significantly higher than that of group B and group C (all P <0.05). The main adverse reactions were bloating, acid reflux and nausea. There were 8 cases (8 / 70,11.43%) in group A, 6 cases (6/66 and 9.09%) in group B and 7 cases in group C , 10.77%). Conclusion For patients with type Ⅰ chronic sinusitis may be preferred nasosinusitis oral liquid ambroxol hydrochloride for treatment, the effect is better than either alone, and the drug safety is good.