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探索焦虑性神经症病人焦虑性障碍与痛觉阈值改变的相关性。方法采用无损伤性高频皮肤电刺激，测定２３例焦虑性神经症病人和２３例年龄和性别匹配的正常对照组的躯体感觉阈（ＳＰＴ）、痛觉阈（ＰＰＴ）及相对痛觉阈ＯＲＰＰＴ）；同时对病人组评定焦虑自评量表（ＳＡＳ）。结果焦虑性神经症病人ＰＰＴ明显高于正常对照组（Ｐ＜０．０５）；ＰＰＴ与ＳＡＳ标准分呈极显著负相关（Ｐ＜０．０００５）。结论焦虑性障碍的病理基础与人类内源性疼痛调节系统可能有紧密的生物学联系。
To explore the correlation between anxiety disorders and changes of pain threshold in anxiety neurosis patients. Methods Twenty - three patients with anxiety neurosis and 23 age - and sex - matched normal control subjects were evaluated for somatosensory (SPT), pain threshold (PPT) and relative pain threshold (ORPPT) using high frequency electrical skin stimulation without injury. At the same time, the patient group was assessed for anxiety self-rating scale (SAS). Results The PPT in patients with anxiety neurosis was significantly higher than that in the normal control group (P <0.05). There was a significant negative correlation between PPT and SAS (P <0.0005). Conclusions The pathological basis of anxiety disorders may have close biological associations with human endogenous pain regulators.