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目的探讨妊娠期肝内胆汁淤积症(ICP)的肝功能及总胆汁酸升高程度与围生儿预后的关系。方法回顾性分析在兖矿集团总医院的146例ICP妊娠孕妇的临床资料。根据肝功能及总胆汁酸指标高低分为轻-中度ICP组(A组)与重度ICP组(B组),并对二组ICP孕妇分娩结局进行综合分析。结果 B组孕妇早产发生率、胎儿宫内窘迫、新生儿窒息、围生儿病死率、剖宫产率等均明显高于A组(P<0.05)。结论重度ICP组产妇母胎结局不良,临床上加强母胎监护和生化指标的监测、早期干预,适时终止妊娠,可以改善母胎结局。
Objective To investigate the relationship between liver function and the level of total bile acid in patients with intrahepatic cholestasis of pregnancy (ICP) and the prognosis of perinatal infants. Methods The clinical data of 146 ICP pregnant women in Yankuang General Hospital were retrospectively analyzed. According to the level of liver function and total bile acid, the patients were divided into mild-moderate ICP group (group A) and severe ICP group (group B). The delivery outcomes of ICP pregnant women were analyzed comprehensively. Results The incidence of preterm birth, fetal distress, neonatal asphyxia, perinatal mortality and cesarean section rate in group B were significantly higher than those in group A (P <0.05). Conclusions In the severe ICP group, the outcome of maternal maternal fetus is poor. Monitoring of maternal fetal guardianship and biochemical indexes in clinical practice, early intervention and timely termination of pregnancy can improve the maternal fetal outcome.