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目的观察疏血通注射液和前列地尔联合治疗糖尿病肾病患者的疗效。方法 120例糖尿病肾病患者随机分为二组,每组60例。治疗组在糖尿病常规治疗基础上予疏血通注射液6ml静滴,1次/d,疗程4周,分别于治疗前后检测血肌酐(Scr)、血尿素氮(BUN)、血β2微球蛋白(β2-MG)、血脂及尿微量白蛋白。结果治疗后,二组患者的UAE、BUN、Scr和β2-MG水平均明显下降(P<0.01),且治疗组下降得更为明显(P<0.05或<0.01);二组的全血黏度(高切、低切)、血浆黏度、纤维蛋白原与治疗前相比均有明显改善(P<0.05或<0.01),且以治疗组改善得更为明显;治疗组TC、LDL-C和TG较前明显下降。结论①疏血通注射液能够降低糖尿病肾病患者的微量白蛋白尿,减少血β2-MG及BUN、Scr含量,改善血液流变学,对糖尿病肾病具有保护作用,该药的抗炎作用可能是其作用机制之一。②疏血通注射液还具有调脂作用:使TC、TG、LDL-C降低。
Objective To observe the efficacy of Shuxuetong injection and alprostadil in the treatment of patients with diabetic nephropathy. Methods 120 patients with diabetic nephropathy were randomly divided into two groups, 60 cases in each group. The patients in the treatment group were treated with Shuxuetong Injection (6ml) intravenously once a day for 4 weeks on the basis of conventional treatment of diabetes. Serum creatinine (Scr), blood urea nitrogen (BUN), blood β2 microglobulin (β2-MG), lipids and urine microalbumin. Results After treatment, the levels of UAE, BUN, Scr and β2-MG in the two groups were significantly decreased (P <0.01), and the treatment group decreased more significantly (P <0.05 or <0.01) (High cut, low cut), plasma viscosity, fibrinogen were significantly improved compared with before treatment (P <0.05 or <0.01), and the treatment group improved more significantly; treatment group TC, LDL-C and TG significantly decreased compared with the previous. Conclusion Shuxuetong injection can reduce the patients with diabetic nephropathy microalbuminuria, reduce blood β2-MG and BUN, Scr content, improve blood rheology, has a protective effect on diabetic nephropathy, the anti-inflammatory effect of the drug may be One of its mechanisms. ② Shuxuetong injection also has lipid-lowering effect: the TC, TG, LDL-C decreased.