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目的探讨莫西沙星所致不良反应的特点和规律,为临床安全合理用药提供依据。方法对我院2005年-2011年上报北京市药品不良反应监测中心的93例不良反应报告进行统计分析。结果莫西沙星所致不良反应中最常见的是变态反应占38.7%,其次为神经系统占21%,心血管系统占19.3%,消化系统占12.9%,肌肉反应占4.3%。其中50岁以上的老年患者有58人,占不良反应发生率的62.3%。女性发生药物不良反应(adverse drug reaction,ADR)略高于男性,占不良反应发生率的56.9%。结论临床应重视莫西沙星不良反应的危害性。高龄患者在使用莫西沙星时应慎用,静脉给药时应控制好滴速。
Objective To explore the characteristics and rules of the adverse reaction caused by moxifloxacin and provide the basis for clinical safety and rational drug use. Methods A total of 93 ADR cases reported to Beijing Center for Drug Adverse Reaction Monitoring from 2005 to 2011 in our hospital were analyzed statistically. Results The most common adverse reactions caused by moxifloxacin were allergic reactions (38.7%), neurological system (21%), cardiovascular system (19.3%), digestive system (12.9%) and muscle reaction (4.3%). Among them, there are 58 elderly patients over the age of 50, accounting for 62.3% of the incidence of adverse reactions. Adverse drug reaction (ADR) in women was slightly higher than that in men, accounting for 56.9% of the incidence of adverse reactions. Conclusion Clinical should pay attention to the harm of the adverse reaction of moxifloxacin. Elderly patients should be used with moxifloxacin caution, intravenous administration should control the drip rate.