【摘 要】
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Dear Editor,Tuberculosis (TB) is a formidable challenge to global health and is caused by an ancient pathogen,Mycobacterium tuberculosis (WHO,2010).In the pre-a
【机 构】
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CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology, CAS, Beijing
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Dear Editor,Tuberculosis (TB) is a formidable challenge to global health and is caused by an ancient pathogen,Mycobacterium tuberculosis (WHO,2010).In the pre-antibiotic era,TB killed 20％ of adults in Europe and North America in the period from the seventeenth to the nineteenth centuries (Wilson,2005).Since antibiotics have been included in TB treatment regimens,millions of human lives have been saved by this chemotherapy.However,the standard anti-tuberculosis therapy is only effective for drug-susceptible TB but not for multi-drug resistant and extensively drug-resistant TB.Unfortunately,our knowledge of drug resistance in mycobacteria remains unclear and thus hampers the development of new antitubercular drugs.The basic mechanisms of drug resistance in mycobacteria are complicated and the outcome of drug resistance stems from evolution in the final analysis.Understanding the evolutionary strategies used by M.tuberculosis might give new insights into designing control strategies against M.tuberculosis (Little et al,.2012).
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