,A partial pathway-and network-based transformation reveals the synergistic mechanism of JA and UA a

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Dear Editor,Ischemic stroke falls under the category of complex diseases,which do not obey the single-gene dominant or single-gene recessive Mendelian patte of inheritance but rather arises from the combination of numerous genetic variants and environmental factors (Cho et al.,2012).Given this degree of complexity,a single compound could never be expected to manage or reverse the effects of a stroke.Recently there has been accumulating evidence suggesting that combination therapies could exert a significant effect on areas affected by a cerebral ischemic stroke.Combination therapies that simultaneously impact multiple targets have promise in the control of complex diseases by way of synergy (Li et al.,2011).
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