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血浆置换(PE) 利用血浆分离机,进行血浆置换,可换出4-5升含抗-D的血浆,输入白蛋白/晶体。然而置换后,体内IgG的合成未抑制,所以一周内应置换2-3次以维持抗-D的低水平。由于PE疗效不稳定,而且许多妇女不接受这种繁琐的疗程,因此该技术使用受限。一般的如果曾有流产史或胎儿受害严重,同时父亲又很可能是RhD纯合子,并且妊娠能维持到顺利探索到脐带,或IVT采样输血可安全进行话,医生会推荐PE。如果选择了PE,就应尽早进行,可在26-28周前避免潜藏的免疫因子(如羊膜穿刺术)的影响。
Plasma exchange (PE) Plasma exchange using a plasma separator converts 4-5 liters of anti-D containing plasma into albumin / crystals. However, after the replacement, the synthesis of IgG in the body was not inhibited, so it should be replaced 2-3 times a week to maintain the low level of anti-D. Due to the unstable effect of PE and many women do not accept this cumbersome procedure, the use of this technique is limited. General If there was a history of miscarriage or fetus serious, and her father is likely to be homozygous RhD, and pregnancy can be maintained until the umbilical cord has been successfully explored, or IVT sampling transfusion can be safe, the doctor will recommend PE. If you choose PE, it should be as soon as possible, can avoid the impact of hidden immune factors (such as amniocentesis) 26-28 weeks ago.