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目的探讨甲状腺转录因子-1(TTF-1)及天门冬氨酸蛋白酶(NapsinA)在浆膜腔积液肺腺癌细胞中的表达。方法选用浆膜腔积液转移性癌共112例(胸水101例，腹水9例，心包积液2例)。经组织学或结合临床资料证实的肺腺癌86例，肺鳞癌5例，肺小细胞癌2例，卵巢癌13例，乳腺癌3例，胆管癌1例，胃癌1例，胰腺癌1例。每例均制备 HE 染色的涂片和细胞块，并用细胞块切片作 TTF-1及 NapsinA 免疫细胞化学染色。结果86例肺腺癌中 TTF-1的敏感性为84.9%，特异性为96.2%；NapsinA 的的敏感性为88.4%，特异性为100%。结论 NapsinA 在浆膜腔积液肺腺癌中较 TTF-1具有较高的敏感性及特异性。“,”Objective To analyze the expression of TTF -1 and NapsinA in the metastatic pulmonary adenocarcinoma cells in serous effusions. Methods A total of 112 cases of effusion cytology were evaluated.The primary sites of origin were confirmed clinically or histologically in all patients. There were 86 adenocarcinomas from the lung,5 squamous carcinoma from lung,2 small cell carcinoma from lung,13 adenocarcinomas from stomach and 1 adenocarcinomas from pancreas.HE and cell block were prepared for each case.Immunocytochemical study were performed on the cell block sections. Results TTF-1 expressed in 73 lung adenocarcinomas and the sensitivity was 84.9%,specificity was 96.2%,NapsinA expressed in 76 lung adenocarcinomas and the sensitivity was 88.4% ,specificity was 100% . Conclusion NapsinA is a higher sensitive and specific marker for adenocarcinomas of the lung in the serous effusions.