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目的:了解心力衰竭患者长期应用卡维地洛对患者心理状况的影响。方法:对100例慢性充血性心力衰竭(CHF)患者在常规治疗的基础上,开始服用卡维地洛,从小剂量开始,逐渐递增,实验中严密检测各项相关指标。结果:随访98周,随访期间猝死1例。与治疗前比较,99例患者治疗后心功能有明显改善[(2.24±0.79)∶(3.05±0.65)级,P<0.05];6min步行距离有明显进步[(312.71±152.39)∶(203.67±134.86)m,P<0.01];超声心动图示左室射血分数明显增加[(38.9±6.7)%∶(32.8±4.9)%,P<0.01];明尼苏达生活质量量表评分有显著的改善[(23.86±9.64)∶(41.63±13.76)分,P<0.05];反映抑郁状态的SDS评分均稍有改善,但差异无统计学意义(P>0.05);焦虑状态的SAS评分有明显变化(P<0.01)。结论:卡维地洛长期治疗CHF患者除了能明显提高患者的活动耐量、改善心功能外,还能改善其焦虑状况,但对抑郁状况无明显影响。
Objective: To understand the long-term use of carvedilol in patients with heart failure on the psychological status of patients. Methods: 100 patients with chronic congestive heart failure (CHF) on the basis of conventional treatment, began taking carvedilol, starting from a small dose, and gradually increased, the test closely test the relevant indicators. Results: Follow-up of 98 weeks, 1 case of sudden death during follow-up. Compared with before treatment, 99 patients had significant improvement of cardiac function after treatment [(2.24 ± 0.79) vs (3.05 ± 0.65), P <0.05], and significant improvement of walking distance at 6min [(312.71 ± 152.39) :( 203.67 ± 134.86) m, P <0.01]. Echocardiography showed a significant increase in left ventricular ejection fraction [(38.9 ± 6.7)%: (32.8 ± 4.9)%, P <0.01] [(23.86 ± 9.64) vs (41.63 ± 13.76), P <0.05]. The scores of SDS reflecting depression were slightly improved, but the differences were not statistically significant (P> 0.05). SAS scores of anxiety (P <0.01). Conclusion: Carvedilol long-term treatment of CHF patients can significantly improve the patient’s activity tolerance, improve cardiac function, but also improve their anxiety status, but no significant effect on depression.