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目的 探讨nm2 3-H1蛋白与肝细胞肝癌 (HCC)肝内转移的关系。方法 应用免疫组织化学法检测 6 1例HCC癌组织及癌旁肝组织nm2 3-H1蛋白表达。结果 6 1例HCC中 37例 (6 0 .7% )呈阳性表达 ,阳性表达主要位于细胞质 ,nm2 3-H1蛋白表达与年龄、肝功能、肿瘤大小、AFP水平、包膜形成、Edmondson分级、HBsAg无关 (P >0 .0 5 ) ,而与肝内是否转移关系密切 (P <0 .0 5 )。结论 nm2 3-H1蛋白可以抑制HCC肝内转移。
Objective To investigate the relationship between nm23-H1 protein and intrahepatic metastasis of hepatocellular carcinoma (HCC). Methods Immunohistochemistry was used to detect the expression of nm23-H1 protein in 61 cases of HCC and adjacent liver tissue. RESULTS: Of the 61 cases of HCC, 37 cases (60.7 percent) were positively expressed. The positive expression was mainly located in the cytoplasm. The expression of nm2 3-H1 protein was related to age, liver function, tumor size, AFP level, capsule formation, Edmondson classification, HBsAg was not related (P > 0.05), but it was closely related to metastasis in the liver (P < 0.05). Conclusion nm2 3-H1 protein can inhibit intrahepatic metastasis of HCC.