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目的:研究两种不同类型环糊精羟丙基-β-环糊精(HP-β-CD)、γ-环糊精(γ-CD)对吲达帕胺的包合增溶作用,并进行包合物的鉴定。方法:运用相溶解度法考察不同类型环糊精对药物的增溶作用,并用差示扫描量热(DSC)法和红外光谱(IR)法对包合物进行鉴定。结果:确定了吲达帕胺与HP-β-CD和γ-CD包合物的相溶解度图,并计算了表观稳定常数,用DSC法和IR法确证2种不同类型环糊精的包合物均已形成。结论:2种不同类型环糊精对吲达帕胺都有显著的增溶作用,且都能形成包结比为1:1的包合物,γ-CD的增溶作用更强,形成的包合物更稳定。
OBJECTIVE: To study the inclusion and solubilization of indapamide with two different types of cyclodextrins, hydroxypropyl-β-cyclodextrin (HP-β-CD) and γ-cyclodextrin Clarification of the identification. Methods: The solubilities of different types of cyclodextrins were investigated by phase-solubility method. The inclusion complexes were identified by differential scanning calorimetry (DSC) and infrared spectroscopy (IR). Results: Phase solubility plots of indapamide and HP-β-CD and γ-CD inclusion complexes were determined and the apparent stability constants were calculated. Two different types of cyclodextrin packs were confirmed by DSC and IR Compounds have been formed. CONCLUSION: Both of the two types of cyclodextrins have significant solubilization effects on indapamide, and all of them can form inclusion complexes with inclusion ratio of 1: 1, solubilization of γ-CD is stronger, Inclusion is more stable.