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目的:研究C/EBPα蛋白在新疆维吾尔族妇女子宫颈鳞癌组织中的表达及临床意义。方法:采用免疫组化S-P法对36例子宫颈鳞癌组织、26例慢性子宫颈炎组织中C/EBPα蛋白的表达进行检测。结果:新疆维吾尔族妇女慢性子宫颈炎与子宫颈鳞癌组织中C/EBPα蛋白的表达具有显著性差异(P<0.05);并且C/EBPα蛋白的表达与肿瘤的病理分级有关(P<0.05)。结论:C/EBPα蛋白与新疆维吾尔族的子宫颈鳞癌有着密切的关系,该基因可能是一种潜在的抑制子宫颈鳞癌发生的基因。
Objective: To study the expression and clinical significance of C / EBPα protein in cervical squamous cell carcinoma of Uighur women in Xinjiang. Methods: The expressions of C / EBPα protein in 36 cases of cervical squamous cell carcinoma and 26 cases of chronic cervicitis were detected by immunohistochemical S-P method. Results: The expression of C / EBPαprotein in chronic cervicitis and cervical squamous cell carcinoma was significantly different between Xinjiang Uygur women (P <0.05), and the expression of C / EBPα protein was correlated with the pathological grade (P <0.05) . Conclusion: The C / EBPα protein is closely related to the Uigur cervical squamous cell carcinoma in Xinjiang. The gene may be a potential gene that inhibits the occurrence of cervical squamous cell carcinoma.