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目的探讨肝硬化患者13 C美沙西汀呼气试验检测肝功能的特点。方法选取肝硬化患者60例,正常对照组20例,进行13 C美沙西汀呼气试验肝功能检测并与Child-pugh肝功能分级进行比较。结果随着Child-Pugh分级的加重,DOB、MV峰值逐渐降低,峰值时间明显延长,13 C美沙西汀呼气试验的MVmax40、CUM40和CUM120值随着肝功能损害的加重而显著降低,组间差异均有统计学意义(P<0.01)。结论 13 C呼气试验是一种无创、灵敏、定量的肝功能检测方法,能准确、直观地反映肝硬化患者肝功能状况。
Objective To investigate the characteristics of hepatic function detected by 13 C methacetin breath test in cirrhotic patients. Methods Sixty patients with cirrhosis and 20 normal controls were enrolled in this study. The liver function of 13 C methacetin breath test was compared with that of Child-pugh liver function test. Results With the increase of Child-Pugh grading, the peaks of DOB and MV gradually decreased and the peak time was significantly prolonged. The values of MVmax40, CUM40 and CUM120 in 13 C methacetin breath test significantly decreased with the increase of liver dysfunction. The differences were statistically significant (P <0.01). Conclusion 13 C breath test is a noninvasive, sensitive and quantitative method of liver function test, which can accurately and directly reflect the liver function status of patients with cirrhosis.