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目的观察中西药联合治疗慢性乙型肝炎活动期的临床疗效。方法将60例慢性乙型肝炎活动期(肝肾阴虚型)患者随机分为观察组和对照组,每组30例。对照组进行常规西药(抗病毒+护肝)治疗,应用阿德福韦酯片/恩替卡韦片+还原型谷胱甘肽,每天1次。观察组在对照组的基础上辨证应用中药治疗,疗程28d,观察两组患者治疗前后的临床症状、体征及血清总胆红素(TBIL)、谷丙转氨酶(ALT)的变化。结果经过治疗,两组患者的TBIL和ALT均下降,临床症状、体征均改善,但观察组的TBIL和ALT下降的幅度和临床症状改善明显高于对照组,观察组总有效率达93.3﹪高于对照组的76.6%,差异有统计学意义(P<0.05)。结论中西药联合治疗慢性乙型肝炎活动期(肝肾阴虚型)疗效显著。
Objective To observe the clinical efficacy of combined traditional Chinese and western medicine in the treatment of active chronic hepatitis B. Methods Sixty patients with chronic hepatitis B active stage (liver and kidney yin deficiency type) were randomly divided into observation group and control group, 30 cases in each group. Control group for conventional Western medicine (antiviral + liver protection) treatment, the application of adefovir dipivoxil tablets / entecavir tablets + reduced glutathione, 1 times a day. The observation group was treated with traditional Chinese medicine on the basis of the control group. The course of treatment was 28 days. The clinical symptoms and signs and the changes of serum total bilirubin (TBIL) and alanine aminotransferase (ALT) before and after treatment were observed. Results After treatment, the TBIL and ALT of both groups decreased, and the clinical symptoms and signs were improved. However, the decrease of TBIL and ALT and the improvement of clinical symptoms in the observation group were significantly higher than those in the control group. The total effective rate in the observation group was 93.3% 76.6% of the control group, the difference was statistically significant (P <0.05). Conclusion Chinese and Western medicine combined treatment of chronic hepatitis B active stage (liver and kidney yin deficiency type) curative effect.