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目的 :研究黄连素在与环孢素合用时是否影响肾移植受者血清电解质。方法 :回顾性调查分析 36名接受同种异体肾移植术后长期服用CsA的患者 ,同时检测全血CsA浓度、血清电解质和血糖。结果 :合用组与单用组相比 ,血清电解质和血糖除血清Ca以外均无显著差异。两组血清钙经t检验差异具有统计学意义 ,但两组数据的均值都在正常范围内。结论 :合用黄连素不会对肾移植受者的血清电解质产生比单用CsA更大的影响。
OBJECTIVE: To investigate whether berberine affects serum electrolytes in kidney transplant recipients when used in combination with cyclosporine. Methods: Thirty - six patients receiving long - term CsA after renal transplantation were retrospectively analyzed. CsA concentration, serum electrolytes and blood glucose were measured simultaneously. Results: There was no significant difference in serum electrolytes and blood glucose between the combined group and the single group except serum Ca. Two groups of serum calcium differences by t test was statistically significant, but the average of the two groups of data are within the normal range. CONCLUSIONS: Berberine does not produce a greater effect on serum electrolytes in renal transplant recipients than CsA alone.