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胸腺素是从小牛胸腺提取出来的一组多肽(至少12个),其分子量范围为1,200～14,000,此外,还含有少量的单核苷酸、寡核苷酸,醣和脂肪。经初步临床试验,胸腺素治疗原发性免疫缺损病有显著的效果,减少病人的感染情况,增加血中的T细胞数目和淋巴细胞功能以及对回忆试验抗原的迟缓超敏反应。在恶性肿瘤病人中,胸腺素使血中T细胞百分率显著增高。应用胸腺素在动物中和临床上所进行的研究表明自家免疫病可能是胸腺素分泌不足的结果。本文通过所报导的实验结果企图阐明胸腺素在治疗免疫缺损症的功效的前景。
Thymosin is a group of peptides (at least 12) extracted from the calf thymus and has a molecular weight range of 1,200-14,000. In addition, it contains small amounts of mononucleotides, oligonucleotides, sugars and fats. After preliminary clinical trials, thymosin treatment of primary immunodeficiency disease has a significant effect, reduce the patient’s infection, increase the number of T cells in the blood and lymphocyte function, as well as the delayed response hypersensitivity to memory test antigen. In patients with malignant tumors, thymosin significantly increased the percentage of T cells in the blood. Studies using thymosin in animals and in clinics have shown that autoimmune disease may be the result of insufficient thymic hormone secretion. This article attempts to elucidate the prospects for the efficacy of thymosin in the treatment of immunodeficiency disorders through the reported experimental results.