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心室纤颤是急性心肌梗塞病人猝死的主要原因之一,由于心肌梗塞急性期容易发生心室纤颤的真正原因至今尚未阐明,因而有效的防治药物仍在探索之中。过去的研究工作基本上确定了心律失常与梗塞的心肌细胞失钾有关,并且证明缺血心肌细胞质膜钠-钾-三磷酸腺苷酶(Na~+-K~+-ATP酶)活性减低。可是,导致Na~+-K~+-ATP酶活性减低的原因仍未阐明。Opie提出与梗塞心肌ATP生成减低、供给Na~+-K~+-ATP酶能量减少有关;Kurien等提出与梗塞心肌细胞内游离脂肪
Ventricular fibrillation is one of the major causes of sudden death in patients with acute myocardial infarction. Since the real cause of ventricular fibrillation in the acute phase of myocardial infarction has not been elucidated so far, effective prevention and cure drugs are still under investigation. In the past, the research work basically determined that arrhythmia is related to the loss of potassium in infarcted cardiomyocytes and that the plasma membrane Na + -K + ATPase (Na ~ + -K ~ + -ATPase) activity was decreased in ischemic myocardium. However, the reason for the decrease of Na ~ + -K ~ + -ATPase activity has not yet been elucidated. Opie proposed and myocardial infarction myocardial ATP production reduced supply of Na ~ + -K ~ + -ATP enzyme energy reduction; Kurien proposed with myocardial infarction myocardial free fatty