论文部分内容阅读
为了解老年人血脂水平与载脂蛋白E基因多态性的关系．并探讨载脂蛋白E等位基因对老年人血脂水平的内在影响，利用PCR－RFLP法测定了载脂蛋白E基因型，并用酶学方法对其血脂水平进行了测定。结果发现存在五种不同基因型；与携有ε3等位基因的人群相比，携有ε1等位基因的人群倾向具有较高的总胆固醇和低密度脂蛋白胆固醇水平以及较低的甘油三酯水平，而携有ε2等位基因的人群则有较低的低密度脂蛋白胆固醇水平以及较高的甘油三酯水平．但无统计学差异。提示载脂蛋白E等位基因影响老年人的血脂水平，但可能不如成年人显著和明显。
To understand the relationship between serum lipids and apolipoprotein E gene polymorphism in the elderly. And to explore the inherent impact of apolipoprotein E allele on the blood lipid level of the elderly. The apolipoprotein E genotype was determined by PCR-RFLP and its lipid level was determined by enzymology method. As a result, five different genotypes were found; those with the ε1 allele tended to have higher levels of total and LDL cholesterol and lower triglycerides than those with the ε3 allele , While those with the ε2 allele have lower LDL cholesterol levels and higher triglyceride levels. But no statistical difference. Tip Apolipoprotein E allele affects the elderly lipid levels, but may not be as significant and significant as adults.