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①目的 探讨癌旁肝组织与肝癌组织发生之间的关系。②方法 用亲和组织化学的方法检测人肝癌及癌旁组织中6种凝集素受体的表达。③结果肝癌组织菜豆凝集素(PHA)、花生凝集素(PNA)、双花藕豆凝集素(DBA)、荆豆凝集素(UEA—1)受体的阳性率明显高于癌旁组织(x~2＝4.16~53.86,p均<0.01或0.05);肝癌组织西非单叶豆凝集素(BSL)、大豆凝集素(SBA)受体的阳性率与癌旁组织无明显区别(x~2=0.03,0.04,p均>0.05);散在的嗜酸性毛玻璃样肝细胞、嗜酸性细胞结节BSL,SBA受体阳性。④结论嗜酸性毛玻璃样肝细胞、嗜酸性细胞结节与肝癌细胞具有某些相同的糖结合蛋白,嗜酸性细胞结节是肝癌的癌前期病变;BSL,SBA可作为癌前病变的检测指标。
Objective To investigate the relationship between adjacent liver tissue and hepatocellular carcinoma. 2 Methods Affinity histochemistry was used to detect the expression of six lectin receptors in human liver cancer and adjacent tissues. 3 Results The positive rates of PHA, PNA, DBA and UEA-1 receptors in hepatocellular carcinoma were significantly higher than those in adjacent tissues (x ~2=4.16~53.86, p<0.01 or 0.05); the positive rates of hepatoma tissue BSL and SBA receptors were not significantly different from those in adjacent tissues (x~2= 0.03, 0.04, p all> 0.05); scattered eosinophilic vitreous-like liver cells, eosinophilic nodules BSL, SBA receptor positive. 4 Conclusion Eosinophilic glass-like liver cells, eosinophilic nodules and hepatoma cells have some of the same sugar-binding protein, eosinophilic nodules are precancerous lesions of liver cancer; BSL, SBA can be used as a detection index of precancerous lesions.