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目的探讨C反应蛋白(CRP)与脂蛋白(a)[LP(a)]在急性冠状动脉综合征(ACS)中的相关性及其临床应用价值,以为临床提供参考依据。方法选取本院收治的180例ACS患者,并按照病情分为急性心肌梗死(AMI)组和不稳定心绞痛(UAP)组,每组90例,另选取健康人群50例作为对照组;180例患者进行冠状动脉造影检查,根据结果又分为单支病变组55例,双支病变组59例,三支病变组66例,对所有研究对象的血清CRP、LP(a)进行检测。结果在性别、年龄方面,ACS组与对照组比较差异不具有显著性(P均>0.05)。血清CRP、LP(a)水平方面,AMI组和UAP组与对照组比较均明显升高,且组间差异具有显著性(P均<0.05)。单支病变组、双支病变组和三支病变组均高于对照组,组间差异具有显著性(P均<0.01);且在不同病变支数组间两两比较差异具有显著性(P均<0.01)。联合检测两个指标ACS的阳性率明显高于单独检测一项指标的阳性率。患者血清中CRP与LP(a)水平呈现出明显的正相关,且以上两个指标与冠状动脉的病变支数亦呈现出相关性。结论 CRP与LP(a)是具有相关性的两个指标,在ACS患者中联合检测这两个指标具有重要的意义,能够提高疾病的诊断率,可在临床中进行推广应用。
Objective To investigate the relationship between C-reactive protein (CRP) and lipoprotein (a) [LP (a)] in acute coronary syndrome (ACS) and its clinical value in order to provide reference for clinical practice. Methods One hundred and eighty ACS patients admitted to our hospital were enrolled and divided into AMI group and UAP group according to the condition, 90 cases in each group and 50 healthy people as control group. 180 cases Coronary angiography was performed. According to the results, 55 cases of single-vessel disease group, 59 cases of double-vessel disease group and 66 cases of three-vessel disease group were selected. Serum CRP and LP (a) were detected in all subjects. Results There were no significant differences in gender and age between ACS group and control group (all P> 0.05). Serum CRP, LP (a) levels, AMI group and UAP group were significantly increased compared with the control group, and the difference between groups was significant (P all <0.05). The single-vessel lesion group, double-vessel lesion group and three-vessel lesion group were higher than the control group, with significant difference between the two groups (all P <0.01), and there was significant difference between the two groups (P <0.01). The combined detection of two indicators of ACS positive rate was significantly higher than the single detection of an indicator of the positive rate. Serum CRP and LP (a) levels showed a significant positive correlation, and the above two indicators and the coronary artery lesions also showed a correlation. Conclusions CRP and LP (a) are two related indicators. It is of great significance to jointly measure these two indexes in patients with ACS, which can improve the diagnosis rate of the disease and can be popularized and applied in the clinic.