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目的探讨原发性高血压患者颈动脉粥样硬化(CAS)斑块形成与血尿酸(UA)的关系。方法选择146例住院高血压患者经查血尿酸(UA)、C-反应蛋白(CRP)及其他生化指标,行颈动脉超声检查并据其结果分组,原发性高血压病患者颈动脉斑块形成者为斑块组74例,无颈动脉斑块形成者为对照组72例。比较两组血尿酸、CRP及其他生化指标。结果两组年龄、总胆固醇(TC)无明显差异(P>0.05),但斑块组病程、体表指数(BMI)、血UA、CRP及低密度脂蛋白(LDL-C)、甘油三酯(TG)较对照组明显升高(P<0.01和P<0.05),差异有统计学意义;UA与CRP呈正相关(r=0.713,P<0.01)。结论高血压患者颈动脉斑块形成与血尿酸、C-反应蛋白密切相关,且二者呈正相关。
Objective To investigate the relationship between carotid atherosclerosis (CAS) plaque formation and serum uric acid (UA) in patients with essential hypertension. Methods A total of 146 inpatients with hypertension were enrolled in this study. Uric acid (C-reactive protein) and other biochemical parameters were examined. Carotid ultrasonography was performed and grouped according to the results. Carotid plaques The formation of plaque group 74 cases, no carotid artery plaque formation for the control group of 72 cases. Blood uric acid, CRP and other biochemical parameters were compared between the two groups. Results There were no significant differences in age and total cholesterol between the two groups (P> 0.05). However, the duration of disease, body surface index (BMI), blood UA, CRP and LDL- (P <0.01 and P <0.05). There was a significant positive correlation between UA and CRP (r = 0.713, P <0.01). Conclusion The formation of carotid plaques in patients with hypertension is closely related to serum uric acid and C-reactive protein, and the two are positively correlated.