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“回春仙”制剂是以补益心肾,填精益血为组方原则组成的一种抗衰益寿,防治以心脑血管系统疾病为主的中药复方制剂。为探讨服用“回春仙”对遗传物质有否潜在损伤,我们以小鼠骨髓嗜多染成红细胞(PCE)微核率,染色体畸变率(CA)和姐妹染色单体交换(SC E)频率为指标对这个问题进行了研究。现报告如下: 材料与方法“回春仙”中药复方制剂是从何首乌、当归等六味中药中分别提取各药物的有效成分,按一定比例组合而成。环磷酰胺购自上海第十二制药厂。实验动物由农业部哈尔滨兽医研究所提供。 (一)小鼠骨髓细胞CA和SCE试验 BALB/C纯系小鼠,体重18～20克,随
“Rejuvenation Xian” preparation is a kind of anti-aging and longevity composed by replenishing heart and kidney, filling lean and benefiting blood as the principle of prescription, and it is used to prevent and treat traditional Chinese medicine compound preparations based on cardiovascular and cerebrovascular diseases. To investigate whether there is any potential damage to the genetic material by taking “rejuvenation cents”, we used the micronuclear rate of polychromatic erythroblasts (PCE) in mouse bone marrow, the chromosome aberration rate (CA) and sister chromatid exchange (SC E) frequency Indicators have studied this issue. The report is as follows: Materials and Methods “Rejuvenation” Chinese herbal compound preparations are extracted from the six herbs of fleece-flower root, angelica, etc., respectively, the active ingredients of each drug, combined by a certain ratio. Cyclophosphamide was purchased from Shanghai No. 12 Pharmaceutical Factory. Experimental animals were provided by Harbin Veterinary Research Institute of the Ministry of Agriculture. (A) Mouse bone marrow cells CA and SCE test BALB/C pure mice, weighing 18 to 20 grams, with