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采用秘灵王（ＭＬＷ）灌喂正常Ｓｗｉｓｓ鼠与先天性免疫缺陷裸鼠，观察ＭＬＷ对两品系小鼠免疫功能的影响，探讨ＭＬＷ的免疫调节效应。结果表明，ＭＬＷ可显著促进Ｓｗｉｓｓ鼠Ｔ、Ｂ细胞对丝裂原的反应性；促进胸腺细胞与骨髓细胞的自发增殖；促进脾细胞产生ＩＬ－１、ＩＬ－６的能力（Ｐ＜０．０１）。ＭＬＷ对裸鼠仅可促进Ｂ细胞对ＧＰＳ的反应性（Ｐ＜０．０５）。裸鼠与Ｓｗｉｓｓ鼠比较，裸鼠Ｂ细胞对ＬＰＳ、ＧＰＳ的反应性、骨髓细胞自发增殖、血清ＣＩＣ水平等指标均高于Ｓｗｉｓｓ鼠（０．０１＜Ｐ＜０．０５），而胸腺细胞自发增殖、血清溶菌酶含量、脾ＭΦ精氨酸酶水平均低于Ｓｗｉｓｓ鼠（Ｐ＜０．０５）。提示ＭＬＷ对正常鼠及免疫缺陷鼠有不同的免疫调节效应。
The normal Swiss mice and congenital immunodeficient nude mice were fed with MLW to observe the effect of MLW on the immune function of the two strains of mice and to explore the immunomodulatory effect of MLW. The results showed that MLW could significantly promote the reactivity of T and B cells in Swiss mice to mitogen, promote the spontaneous proliferation of thymocytes and myeloid cells, and promote the production of IL-1 and IL-6 by spleen cells (P <0.01) ). MLW can only promote the reactivity of B cells to GPS in nude mice (P <0.05). Compared with Swiss mice, B cells in nude mice showed higher response to LPS and GPS, spontaneous proliferation of bone marrow cells and serum CIC levels than those in Swiss mice (P <0.05) Proliferation, serum lysozyme content, and spleen MΦ arginase levels were lower than those in Swiss mice (P <0.05). Tip MLW on normal and immunodeficient mice have different immunomodulatory effects.