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药物代谢即药物的生物转化过程,研究药物代谢对于了解药物在体内的变化过程至关重要。药物代谢研究的方法主要分为体内和体外两种。体内代谢法因药物在生物体内的分布较广,加上代谢转化的器官和酶系的多样性,使药物及其代谢产物在体内的浓度比较低,代谢产物的检测具有一定的困难。体外代谢法在短时间内可以得到大量的代谢
Drug metabolism is the process of drug biotransformation, and studying drug metabolism is crucial for understanding the process of drug in vivo. The methods of drug metabolism research are mainly divided into two kinds in vivo and in vitro. In vivo metabolism due to the wide distribution of drugs in the body, coupled with the metabolic transformation of organs and enzyme diversity, the drug and its metabolites in vivo concentration is relatively low, the detection of metabolites have some difficulties. In vitro metabolism in a short period of time can be a lot of metabolism