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目的探讨对新生儿窒息后喂养不耐受症采用口服小剂量红霉素治疗的临床效果。方法将69例喂养不耐受的窒息新生儿随机分为治疗组36例,给予口服小剂量红霉素;对照组33例,给予常规治疗。结果治疗组在治疗1 d后胃残余量(GVR)较出生时减少了约1/2[(31.78±36.29)%vs(75.31±54.23)%],3 d后GRV[(9.09±17.98)%]降至10%以下,治疗组GRV改善情况明显优于对照组(P均<0.01);治疗组在不耐受缓解时间、达全胃肠喂养时间、恢复出生体重时间及住院天数上均明显短于对照组(P均<0.01)。结论口服小剂量红霉素治疗窒息后新生儿喂养不耐受症效果满意。
Objective To investigate the clinical effect of oral administration of low dose erythromycin in neonatal asphyxia after feeding intolerance. Methods Sixty-nine neonates with intolerant asphyxia were randomly divided into treatment group (n = 36) and oral low-dose erythromycin (n = 33). The control group (n = 33) was given routine treatment. Results The gastric residual volume (GVR) decreased by about 1/2 [(31.78 ± 36.29)% vs (75.31 ± 54.23)%] at 1 d after treatment in the treatment group. GRV [(9.09 ± 17.98)% ] To below 10%, the improvement of GRV in the treatment group was significantly better than that in the control group (all P <0.01). The treatment group showed obvious improvement in the duration of intolerance, total gastrointestinal feeding, birth weight recovery and length of stay Shorter than the control group (all P <0.01). Conclusion Oral administration of low dose of erythromycin in neonates with asphyxia after feeding suffocation is effective.