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肾素-血管紧张素-醛固酮系统对血压调节与高血压形成都有重要影响。巯甲丙脯酸(captopril),是口服有效的血管紧张素I(ATI)转换酶抑制剂。本文报告系选自我院内科住院病人41例,血压在230～150/150～100mmHg的患者使用此药进行疗效观察。本组病例中。男18人,女23人,年龄27～69岁,(平均年龄50.1岁)。均诊断为高血压病Ⅱ～Ⅲ期。除个别病例外,均接受过利尿剂、β受体阻滞剂和复方降压片等治疗,效果不满意而改服此药。治疗前及治疗过程中均做血尿便常规检查,肝肾功能检查、血清钾、钠、氯及心脏X光片、心电图及超声心动图检查,每日测量血压1～2次。治疗前停用其它降压药,开始剂量12.5mg,每日三次,连
The renin-angiotensin-aldosterone system has important effects on both blood pressure regulation and hypertension. Captopril, an orally available angiotensin I (ATI) converting enzyme inhibitor. This article reports 41 patients hospitalized in our hospital for internal medicine and blood pressure of 230 ~ 150/150 ~ 100mmHg in patients with the efficacy of this drug. In this group of patients. 18 males and 23 females, aged from 27 to 69 (mean age 50.1 years). All were diagnosed as hypertensive disease Ⅱ ~ Ⅲ period. In addition to individual cases, have received diuretics, β-blockers and compound antihypertensive tablets and other treatment, the effect is not satisfied and change the service. Hematuria routine examination, liver and kidney function tests, serum potassium, sodium, chlorine and X-ray, electrocardiogram and echocardiography were performed before and during the treatment. Blood pressure was measured 1 to 2 times a day. Before treatment, disable other antihypertensive drugs, the initial dose of 12.5mg, three times a day, and even