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目的观察α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变的临床疗效。方法 68例糖尿病周围神经病变患者,按照治疗方法不同分为对照组及观察组,各34例。对照组给予甲钴胺治疗,观察组患者在对照组基础上给予α-硫辛酸联合治疗,比较两组患者的临床疗效。结果观察组患者总有效率为94.12%,显著高于对照组的76.47%,差异具有统计学意义(P<0.05)。观察组神经代谢紊乱症状改善系数、氧化应激降低水平和血管损伤修复指数评分均明显优于对照组,差异具有统计学意义(P<0.05)。结论α-硫辛酸联合甲钴胺对糖尿病周围神经病变的临床疗效确切,且患者临床症状均得到明显改善,值得临床推广应用。
Objective To observe the clinical efficacy of α-lipoic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy. Methods Sixty-eight patients with diabetic peripheral neuropathy were divided into control group and observation group according to different treatment methods, 34 cases in each. The control group was treated with methylcobalamin. Patients in the observation group were given α-lipoic acid combination therapy on the basis of the control group, and the clinical efficacy was compared between the two groups. Results The total effective rate of the observation group was 94.12%, which was significantly higher than that of the control group (76.47%), the difference was statistically significant (P <0.05). Observation group, neurological metabolic disorder improvement factor, decreased oxidative stress and vascular injury repair index scores were significantly better than the control group, the difference was statistically significant (P <0.05). Conclusions α-lipoic acid combined with mecobalamin has definite therapeutic effect on diabetic peripheral neuropathy, and the clinical symptoms of patients have been significantly improved, which is worthy of clinical application.